The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children
Identifieur interne : 002007 ( Main/Exploration ); précédent : 002006; suivant : 002008The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children
Auteurs : Mark C. Steinhoff [États-Unis] ; Neal A. Halsey [États-Unis] ; Louis F. Fries [États-Unis] ; Modena H. Wilson [États-Unis] ; James King [États-Unis] ; Barbara A. Burns [États-Unis] ; Roberta K. Samorodin [États-Unis] ; Victoria Perkis [États-Unis] ; Brian R. Murphy [États-Unis] ; Mary Lou Clements [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1991.
Abstract
Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.
Url:
DOI: 10.1093/infdis/163.5.1023
Affiliations:
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Steinhoff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="King, James" sort="King, James" uniqKey="King J" first="James" last="King">James King</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Burns, Barbara A" sort="Burns, Barbara A" uniqKey="Burns B" first="Barbara A." last="Burns">Barbara A. 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Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University Chicago Press</publisher><date when="1991-05">1991</date><biblScope unit="vol">163</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1023">1023</biblScope><biblScope unit="page" to="1028">1028</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name></region><name sortKey="Burns, Barbara A" sort="Burns, Barbara A" uniqKey="Burns B" first="Barbara A." last="Burns">Barbara A. Burns</name><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><name sortKey="King, James" sort="King, James" uniqKey="King J" first="James" last="King">James King</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Perkis, Victoria" sort="Perkis, Victoria" uniqKey="Perkis V" first="Victoria" last="Perkis">Victoria Perkis</name><name sortKey="Samorodin, Roberta K" sort="Samorodin, Roberta K" uniqKey="Samorodin R" first="Roberta K." last="Samorodin">Roberta K. Samorodin</name><name sortKey="Steinhoff, Mark C" sort="Steinhoff, Mark C" uniqKey="Steinhoff M" first="Mark C." last="Steinhoff">Mark C. Steinhoff</name><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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